The LD50 of DOM is between 100 - 125 mg/kg for a mouse. This is one of the last of the experimental compounds within the phenethylamine family on which any animal toxicity studies were performed prior to human studies. DOM is the amphetamine analogue of the phenethylamine 2C-D.
DOM contains methoxy functional groups (OCH 3) attached to carbons R 2 and R 5 and a methyl group attached to carbon R 4 of the phenyl ring. Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH 2) group through an ethyl chain and a methyl group bound to the alpha carbon R α. ChemistryĭOM, or 4-methyl-2,5-dimethoxyamphetamine, is a molecule of the substituted amphetamine class. Second, treatment of such overdoses was complicated by the fact that it was unknown at the time that the tablets called "STP" were DOM. This, combined with DOM’s slow onset of action (which encouraged some users, familiar with substances that have quicker onsets, such as LSD, to re-dose) and its remarkably long duration, caused many users to panic and sent some to the emergency room. First, the tablets contained an excessively high dose of the chemical. This short-lived appearance of DOM on the black market proved disastrous for several reasons. In mid-1967, tablets containing 20 mg (later 10 mg) of DOM were widely distributed in the Haight-Ashbury District of San Francisco under the name of "STP" (short for "Serenity, Tranquility, and Peace"). They are found within the first book of PiHKAL and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7.
DOM is part of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine compounds, all of which except mescaline he developed and synthesized himself. Many reports also indicate that the effects of this chemical may be overly difficult to use for those who are not already experienced with psychedelics.ĭOM was first synthesized and tested in 1963 by Alexander Shulgin, who was investigating the effect of 4-position substitutions on psychedelic amphetamines.
Over the years, DOM has gained a reputation for being a highly dose-sensitive psychedelic that is often sold on blotting paper and known for its strong visuals, body load and neutral, analytical headspace. In 1991, the synthesis and pharmacology of DOM was published in Shulgin's book PiHKAL ("Phenethylamines I Have Known And Loved"). It attained some popularity during the summer of 1967 under the name "STP" ("Serenity, Tranquility, and Peace"), but its use was short-lived due to its side effects. It produces its effects by acting on serotonin receptors in the brain.ĭOM was first synthesized and tested in 1963 by Alexander Shulgin. DOM is a member of the DOx family of compounds which are known for their high potency, long duration, and mixture of psychedelic and stimulant effects.
It is not a recommendation and should be verified with other sources for accuracy.Ģ,5-Dimethoxy-4-methylamphetamine (also known as DOM and STP or "Serenity, Tranquility and Peace") is a lesser-known psychedelic substance of the amphetamine class. See responsible use section.ĭISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. DOM, STP (Serenity, Tranquility, and Peace)ġ-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane
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